| Description | BAG Cochaperone 2 |
| Category | Protein Coding |
| GIFtS | 39 |
| GC id | GC06P057172 |
| Score | 3.77 |
| Entrez Gene Summary | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] |
| GeneCards Summary | BAG2 (BAG Cochaperone 2) is a Protein Coding gene. Diseases associated with BAG2 include Carpenter Syndrome 1. Among its related pathways are Cellular response to heat stress and Regulation of degradation of deltaF508 CFTR in CF. Gene Ontology (GO) annotations related to this gene include identical protein binding and chaperone binding. |
| Gene Database | GeneCards: The Human Gene Database |
| Price | Inquiry |
