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Cat. No.: TCELL-0062

HGT-1

Description The HGT-1 cell line was derived from a primary gastric adenocarcinoma tumor removed from a 60 year old Moroccan male of O Rh - blood group. At the time of the operation, the primary tumor showed no signs of metastasis but did exhibit poor differentiation. HGT-1 cells show hyperdiploid karyotype with a modal number of 57 chromosomes and are shown to be tumorgenic in nude mice. They also display functional histamine H 2 -receptors mediating cellular cyclic adenosine 3':5'-monophosphate production and adenylate cyclase activation. HGT-1 cells may have applications in the in vitro study of stomach cancer helping to identify the gene drives associated with gastric cancers.
Species Human
Donor Disease Esophagogastric Adenocarcinoma
Disease Subtype Stomach Adenocarcinoma
Donor Gender Male
Donor Age 60
Donor Ethnicity Moroccan
Tissue/Organ/Organ System Esophagus/Stomach
Cell Morphology Epithelial-like, Polygonal
Population Doubling Time 19 hours
Quality Control 1) Calculated the growth curve of HGT-1 cells at passage 40 (Chart 1). 2) Observed morphology of HGT-1 cells at passage 70 3) Analyzed morphology of the primary tumor through microscopy (Figure 4). 4) Characterized the chromosomal markers and defects HGT-cells karyotype. (Table 1). 5) Tested the production of cyclic AMP and adenylate cyclase activity after the introduction of histamine alone or with cimetidine (Table 2)
Size 1*106 cells/1.0 ml
Format Frozen
Application For Research Use Only
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